Low Correlation between MIC and Mutant Prevention Concentration

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Low correlation between MIC and mutant prevention concentration.

Soon after the term mutant prevention concentration (MPC) was coined to define the MIC of the least susceptible mutant subpopulation of a microbial culture (2), we noticed that MPCs and MICs correlated poorly (r 2 0.39) for a set of closely related fluoroquinolones when determined with Mycobacterium smegmatis (9). Subsequently, isolated examples were described in which correlation was low for a...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 2006

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.50.1.403-404.2006